Version 5.4
Bos taurus Protein: NCDN
Summary
InnateDB Protein IDBP-693905.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCDN
Protein Name Neurochondrin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000033145
InnateDB Gene IDBG-641529 (NCDN)
Protein Structure
UniProt Annotation
Function Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)- calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031175 neuron projection development
GO:0045453 bone resorption
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030425 dendrite
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJ97
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505994
UniGene Bt.39963
RefSeq NP_001039396
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105450 BT029822
GenPept AAI05451 ABM06085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca