InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIR2DL4

Summary

InnateDB Protein

IDBP-69391.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIR2DL4

Protein Name

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4

Synonyms

CD158D; G9P; KIR-103AS; KIR103; KIR103AS;

Species

Homo sapiens

Ensembl Protein

ENSP00000350088

InnateDB Gene

IDBG-69383 (KIR2DL4)

Protein Structure

UniProt Annotation

Function

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	10 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR013151 Immunoglobulin

PFAM

PF00047

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99706

PhosphoSite

PhosphoSite-Q99706

TrEMBL

C3VNC8

UniProt Splice Variant

Entrez Gene

3805

UniGene

Hs.661219

RefSeq

HUGO

HGNC:6332

OMIM

604945

CCDS

HPRD

16082

IMGT

EMBL

AC011501 AF002979 AF002980 AF002981 AF002982 AF003116 AF003117 AF003118 AF003119 AF003120 AF003121 AF003122 AF003123 AF034771 AF034772 AF034773 AF110032 AF110033 AF110034 AF110035 AL133414 EU194342 FJ878883 FJ878884 FJ878885 U71199 U73394 X97229 X99479 X99480 X99481

GenPept

AAB49756 AAB61926 AAB71387 AAB71388 AAB71389 AAB71390 AAB95164 AAB95165 AAB95166 AAC51146 AAD24763 ABW73961 ACP20196 ACP20199 ACP20202 ACP20203 CAA65868 CAA67842 CAA67843 CAA67844 CAC40708