InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: UBA52

Summary

InnateDB Protein

IDBP-694039.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA52

Protein Name

Ubiquitin-60S ribosomal protein L40Ubiquitin60S ribosomal protein L40

Synonyms

RPS27A; UBB; UBC;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010176

InnateDB Gene

IDBG-641655 (UBA52)

Protein Structure

UniProt Annotation

Function

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). {ECO:0000250}.60S ribosomal protein L40: Component of the 60S subunit of the ribosome. {ECO:0000250}.

Subcellular Localization

Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.60S ribosomal protein L40: Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

Biological Process

GO:0006412

translation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000626 Ubiquitin-like
IPR001975 Ribosomal protein L40e
IPR019956 Ubiquitin
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF01020
PF11976

PRINTS

PR00348

PIRSF

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P63048

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

615199

UniGene

Bt.13691

RefSeq

NP_001069831

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB098957 BC102248

GenPept

AAI02249 BAC56447