Version 5.4
Bos taurus Protein: JOSD1
Summary
InnateDB Protein IDBP-694055.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JOSD1
Protein Name Josephin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013418
InnateDB Gene IDBG-641674 (JOSD1)
Protein Structure
UniProt Annotation
Function Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR006155 Machado-Joseph disease protein MJD
PFAM PF02099
PRINTS PR01233
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EAE5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510781
UniGene Bt.22223
RefSeq NP_001014898
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140477 BT020624
GenPept AAI40478 AAX08641

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca