Version 5.4
Bos taurus Protein: LIAS
Summary
InnateDB Protein IDBP-694143.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIAS
Protein Name Lipoyl synthase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019299
InnateDB Gene IDBG-641738 (LIAS)
Protein Structure
UniProt Annotation
Function Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255HAMAP-Rule:MF_03123}.
Subcellular Localization Mitochondrion {ECO:0000255HAMAP- Rule:MF_03123}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity
GO:0016992 lipoate synthase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0001843 neural tube closure
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0009107 lipoate biosynthetic process
GO:0009249 protein lipoylation
GO:0032496 response to lipopolysaccharide
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR003698 Lipoyl synthase
IPR006638 Elongator protein 3/MiaB/NifB
IPR007197 Radical SAM
PFAM PF04055
PRINTS
PIRSF PIRSF005963
SMART SM00729
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BIP7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 530865
UniGene Bt.9756
RefSeq NP_001017944
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT021177
GenPept AAX31359

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca