Version 5.4
Bos taurus Protein: PIK3R2
Summary
InnateDB Protein IDBP-694158.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3R2
Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003033
InnateDB Gene IDBG-641759 (PIK3R2)
Protein Structure
UniProt Annotation
Function Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0035014 phosphatidylinositol 3-kinase regulator activity
Biological Process
GO:0007165 signal transduction
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
Cellular Component
GO:0005622 intracellular
GO:0005942 phosphatidylinositol 3-kinase complex
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF00017
PF14633
PF00018
PF14604
PRINTS PR00401
PR00452
PR00678
PIRSF
SMART SM00324
SM00252
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23726
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282308
UniGene Bt.515
RefSeq NP_777001
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118113 M61746
GenPept AAA79510 AAI18114

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca