InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EP300

Summary

InnateDB Protein

IDBP-694280.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EP300

Protein Name

E1A binding protein p300

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021556

InnateDB Gene

IDBG-641857 (EP300)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 440 interaction(s) predicted by orthology.

Predicted by orthology
Total	440 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001085	RNA polymerase II transcription factor binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004468	lysine N-acetyltransferase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016407	acetyltransferase activity
GO:0016746	transferase activity, transferring acyl groups
GO:0031490	chromatin DNA binding
GO:0033613	activating transcription factor binding
GO:0035257	nuclear hormone receptor binding
GO:0050681	androgen receptor binding
GO:0097157	pre-mRNA intronic binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0001756	somitogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006475	internal protein amino acid acetylation
GO:0006915	apoptotic process
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0007623	circadian rhythm
GO:0009887	organ morphogenesis
GO:0016573	histone acetylation
GO:0018076	N-terminal peptidyl-lysine acetylation
GO:0018393	internal peptidyl-lysine acetylation
GO:0030324	lung development
GO:0032092	positive regulation of protein binding
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043627	response to estrogen
GO:0043923	positive regulation by host of viral transcription
GO:0043967	histone H4 acetylation
GO:0043969	histone H2B acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060765	regulation of androgen receptor signaling pathway
GO:0090043	regulation of tubulin deacetylation

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000197 Zinc finger, TAZ-type
IPR000433 Zinc finger, ZZ-type
IPR001487 Bromodomain
IPR003101 Coactivator CBP, KIX domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010303 Domain of unknown function DUF902, CREBbp
IPR011011 Zinc finger, FYVE/PHD-type
IPR013178 Histone H3-K56 acetyltransferase, RTT109
IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking

PFAM

PF02135
PF00569
PF00439
PF02172
PF06001
PF08214
PF09030

PRINTS

PR00503

PIRSF

SMART

SM00551
SM00291
SM00297

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1B8D6

UniProt Splice Variant

Entrez Gene

UniGene

Bt.65211

RefSeq

HUGO

HGNC:3373

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02014725 DAAA02014726 DAAA02014727 DAAA02014728

GenPept