InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.44422

Summary

InnateDB Protein

IDBP-694301.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.44422

Protein Name

Tyrosine-protein kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027857

InnateDB Gene

IDBG-641863 (BT.44422)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0002731	negative regulation of dendritic cell cytokine production
GO:0006468	protein phosphorylation
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0032693	negative regulation of interleukin-10 production
GO:0032695	negative regulation of interleukin-12 production
GO:0035556	intracellular signal transduction
GO:0035771	interleukin-4-mediated signaling pathway
GO:0043029	T cell homeostasis
GO:0045221	negative regulation of FasL biosynthetic process
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050868	negative regulation of T cell activation
GO:0070232	regulation of T cell apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0070670	response to interleukin-4
GO:2000670	positive regulation of dendritic cell apoptotic process
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005856	cytoskeleton
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020775 Tyrosine-protein kinase, non-receptor Jak3

PFAM

PF00069
PF00017
PF14633
PF07714
PF00373

PRINTS

PR00401
PR00109
PR01823
PR01826

PIRSF

PIRSF000636

SMART

SM00252
SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References