InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CSN2

Summary

InnateDB Protein

IDBP-695353.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSN2

Protein Name

Beta-caseinCasoparanAntioxidant peptideCasohypotensin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003409

InnateDB Gene

IDBG-642853 (CSN2)

Protein Structure

UniProt Annotation

Function

Important role in determination of the surface properties of the casein micelles.Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.Antioxidant peptide has antioxidant activity.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Mammary gland specific. Secreted in milk.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0016209	antioxidant activity
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0006810	transport
GO:0007595	lactation
GO:0008217	regulation of blood pressure
GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity