Version 5.4
Bos taurus Protein: EREG
Summary
InnateDB Protein IDBP-695554.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EREG
Protein Name epiregulin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013571
InnateDB Gene IDBG-643034 (EREG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008285 negative regulation of cell proliferation
GO:0009299 mRNA transcription
GO:0019221 cytokine-mediated signaling pathway
GO:0042108 positive regulation of cytokine biosynthetic process
GO:0042327 positive regulation of phosphorylation
GO:0043616 keratinocyte proliferation
GO:0045089 positive regulation of innate immune response
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0045840 positive regulation of mitosis
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048146 positive regulation of fibroblast proliferation
GO:0051151 negative regulation of smooth muscle cell differentiation
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
PFAM PF00008
PRINTS
PIRSF
SMART SM00181
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BBE2
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:3443
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018097
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca