Version 5.4
Bos taurus Protein: PTGIS
Summary
InnateDB Protein IDBP-695722.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGIS
Protein Name Prostacyclin synthase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023313
InnateDB Gene IDBG-643178 (PTGIS)
Protein Structure
UniProt Annotation
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Subcellular Localization Endoplasmic reticulum membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008116 prostaglandin-I synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016853 isomerase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006693 prostaglandin metabolic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0055114 oxidation-reduction process
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29626
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282021
UniGene Bt.5247
RefSeq NP_776869
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120087 D30718 L34208 S67757
GenPept AAA53674 AAB29680 AAI20088 BAA06383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca