Bos taurus Protein: PTGIS
Summary
InnateDB Protein IDBP-695722.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGIS
Protein Name Prostacyclin synthase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023313
InnateDB Gene IDBG-643178 (PTGIS)
Protein Structure
UniProt Annotation
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Subcellular Localization Endoplasmic reticulum membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008116 prostaglandin-I synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016853 isomerase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006693 prostaglandin metabolic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0055114 oxidation-reduction process
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29626
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282021
UniGene Bt.5247
RefSeq NP_776869
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120087 D30718 L34208 S67757
GenPept AAA53674 AAB29680 AAI20088 BAA06383