InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TMEM237

Summary

InnateDB Protein

IDBP-695802.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMEM237

Protein Name

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4

Synonyms

ALS2CR4;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023181

InnateDB Gene

IDBG-643248 (TMEM237)

Protein Structure

UniProt Annotation

Function

Component of the transition zone in primary cilia. Required for ciliogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250}. Note=Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0030030	cell projection organization
GO:0030111	regulation of Wnt signaling pathway
GO:0042384	cilium assembly

Cellular Component

GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0035869	ciliary transition zone
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

E1BN97

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

515467

UniGene

Bt.68882

RefSeq

NP_001039665

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AAFC03033006 AAFC03033172 BC114141

GenPept

AAI14142