Version 5.4
Bos taurus Protein: GPT
Summary
InnateDB Protein IDBP-696036.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPT
Protein Name Alanine aminotransferase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010309
InnateDB Gene IDBG-643479 (GPT)
Protein Structure
UniProt Annotation
Function Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0042853 L-alanine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00155
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4IFH5
PhosphoSite PhosphoSite-
TrEMBL Q7YRA0
UniProt Splice Variant
Entrez Gene 539188
UniGene Bt.9623
RefSeq NP_001077209
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ518958 BC134583 EU753244
GenPept AAI34584 ACE88261 CAD58795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca