InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FTH1

Summary

InnateDB Protein

IDBP-696113.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FTH1

Protein Name

Ferritin heavy chain

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014853

InnateDB Gene

IDBG-643550 (FTH1)

Protein Structure

UniProt Annotation

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0005515	protein binding
GO:0008199	ferric iron binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006880	intracellular sequestering of iron ion
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0048147	negative regulation of fibroblast proliferation
GO:0055114	oxidation-reduction process