Version 5.4
Bos taurus Protein: ROM1
Summary
InnateDB Protein IDBP-696155.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROM1
Protein Name Rod outer segment membrane protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001574
InnateDB Gene IDBG-643595 (ROM1)
Protein Structure
UniProt Annotation
Function May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations Note=May be involved in mammalian retinopathies.
Tissue Specificity Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007601 visual perception
GO:0010468 regulation of gene expression
GO:0060042 retina morphogenesis in camera-type eye
GO:0060219 camera-type eye photoreceptor cell differentiation
GO:0061298 retina vasculature development in camera-type eye
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042622 photoreceptor outer segment membrane
Protein Structure and Domains
PDB ID
InterPro IPR000830 Peripherin/rom-1
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00218
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P52205
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281465
UniGene Bt.558
RefSeq NP_776599
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118152 D83385 U72027
GenPept AAB17187 AAI18153 BAA11900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca