InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.63550

Summary

InnateDB Protein

IDBP-696183.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.63550

Protein Name

Insulin receptor

Synonyms

ir-A;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016858

InnateDB Gene

IDBG-643606 (BT.63550)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0005009	insulin-activated receptor activity
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031994	insulin-like growth factor I binding
GO:0031995	insulin-like growth factor II binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0043559	insulin binding
GO:0043560	insulin receptor substrate binding
GO:0051425	PTB domain binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019087	transformation of host cell by virus
GO:0023014	signal transduction by phosphorylation
GO:0030238	male sex determination
GO:0030335	positive regulation of cell migration
GO:0031017	exocrine pancreas development
GO:0032147	activation of protein kinase activity
GO:0032148	activation of protein kinase B activity
GO:0032869	cellular response to insulin stimulus
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0042593	glucose homeostasis
GO:0043410	positive regulation of MAPK cascade
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0045821	positive regulation of glycolytic process
GO:0045840	positive regulation of mitosis
GO:0045995	regulation of embryonic development
GO:0046777	protein autophosphorylation
GO:0048639	positive regulation of developmental growth
GO:0051290	protein heterotetramerization
GO:0051897	positive regulation of protein kinase B signaling
GO:0060267	positive regulation of respiratory burst
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005899	insulin receptor complex
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000494 EGF receptor, L domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR006211 Furin-like cysteine-rich domain
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR016246 Tyrosine-protein kinase, insulin-like receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01030
PF00069
PF07714
PF00041
PF01108
PF00757

PRINTS

PR00109

PIRSF

PIRSF000620

SMART

SM00220
SM00060
SM00261
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References