Version 5.4
Bos taurus Protein: PRKAR1A
Summary
InnateDB Protein IDBP-696274.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAR1A
Protein Name cAMP-dependent protein kinase type I-alpha regulatory subunit
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011371
InnateDB Gene IDBG-643694 (PRKAR1A)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Subcellular Localization Cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 76 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004862 cAMP-dependent protein kinase inhibitor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0030552 cAMP binding
GO:0031625 ubiquitin protein ligase binding
GO:0034236 protein kinase A catalytic subunit binding
Biological Process
GO:0001707 mesoderm formation
GO:0001932 regulation of protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007507 heart development
GO:0045214 sarcomere organization
GO:0060038 cardiac muscle cell proliferation
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005886 plasma membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
GO:0031588 AMP-activated protein kinase complex
GO:0031594 neuromuscular junction
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000595 Cyclic nucleotide-binding domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR012198 cAMP-dependent protein kinase regulatory subunit
IPR018490 Cyclic nucleotide-binding-like
PFAM PF00027
PF02197
PRINTS PR00103
PIRSF PIRSF000548
SMART SM00100
SM00394
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00514
PhosphoSite PhosphoSite-P00514
TrEMBL
UniProt Splice Variant
Entrez Gene 615074
UniGene Bt.10903
RefSeq NP_001069826
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118242 BT030573 K00833
GenPept AAA30708 AAI18243 ABQ13013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca