Version 5.4
Homo sapiens Protein: CARD17
Summary
InnateDB Protein IDBP-69630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD17
Protein Name caspase recruitment domain family, member 17
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364859
InnateDB Gene IDBG-547134 (CARD17)
Protein Structure
UniProt Annotation
Function Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. {ECO:0000269PubMed:15383541}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:15383541}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0010951 negative regulation of endopeptidase activity
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5XLA6
PhosphoSite PhosphoSite-Q5XLA6
TrEMBL
UniProt Splice Variant
Entrez Gene 440068
UniGene
RefSeq NP_001007233
HUGO HGNC:33827
OMIM 609490
CCDS CCDS31662
HPRD 17149
IMGT
EMBL AY761064
GenPept AAV28630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca