Version 5.4
Bos taurus Protein: IGFBP5
Summary
InnateDB Protein IDBP-696319.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFBP5
Protein Name Insulin-like growth factor-binding protein 5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009285
InnateDB Gene IDBG-643741 (IGFBP5)
Protein Structure
UniProt Annotation
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0019838 growth factor binding
GO:0031994 insulin-like growth factor I binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0006006 glucose metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0014912 negative regulation of smooth muscle cell migration
GO:0017148 negative regulation of translation
GO:0030336 negative regulation of cell migration
GO:0031069 hair follicle morphogenesis
GO:0040008 regulation of growth
GO:0042593 glucose homeostasis
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0044342 type B pancreatic cell proliferation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060056 mammary gland involution
GO:0071320 cellular response to cAMP
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR012213 Insulin-like growth factor binding protein 5
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
PFAM PF00086
PF00219
PRINTS PR01981
PR01976
PIRSF
SMART SM00211
SM00121
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05717
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 404185
UniGene Bt.55913
RefSeq NP_001098797
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149394 DN511652 S52657
GenPept AAB24874 AAI49395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca