Version 5.4
Bos taurus Protein: APOH
Summary
InnateDB Protein IDBP-696329.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOH
Protein Name beta-2-glycoprotein 1 precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002492
InnateDB Gene IDBG-643750 (APOH)
Protein Structure
UniProt Annotation
Function Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0060230 lipoprotein lipase activator activity
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006641 triglyceride metabolic process
GO:0007597 blood coagulation, intrinsic pathway
GO:0010596 negative regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030193 regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0031639 plasminogen activation
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0051917 regulation of fibrinolysis
GO:0051918 negative regulation of fibrinolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000436 Sushi/SCR/CCP
IPR015104 Beta-2-glycoprotein-1 fifth domain
PFAM PF00084
PF09014
PRINTS
PIRSF
SMART SM00032
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P17690
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281006
UniGene
RefSeq NP_776417
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118364 L07303 X60065
GenPept AAA30382 AAI18365 CAA42669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca