Version 5.4
Bos taurus Protein: SLC11A1
Summary
InnateDB Protein IDBP-696407.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC11A1
Protein Name natural resistance-associated macrophage protein 1
Synonyms NRAMP1;
Species Bos taurus
Ensembl Protein ENSBTAP00000020627
InnateDB Gene IDBG-643814 (SLC11A1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0042803 protein homodimerization activity
GO:0046915 transition metal ion transmembrane transporter activity
GO:0051139 metal ion:proton antiporter activity
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0002309 T cell proliferation involved in immune response
GO:0002369 T cell cytokine production
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006810 transport
GO:0006826 iron ion transport
GO:0006828 manganese ion transport
GO:0006876 cellular cadmium ion homeostasis
GO:0006879 cellular iron ion homeostasis
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007035 vacuolar acidification
GO:0009617 response to bacterium
GO:0010628 positive regulation of gene expression
GO:0015707 nitrite transport
GO:0032147 activation of protein kinase activity
GO:0032623 interleukin-2 production
GO:0032632 interleukin-3 production
GO:0032729 positive regulation of interferon-gamma production
GO:0034341 response to interferon-gamma
GO:0042060 wound healing
GO:0042116 macrophage activation
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0043091 L-arginine import
GO:0045342 MHC class II biosynthetic process
GO:0045730 respiratory burst
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048002 antigen processing and presentation of peptide antigen
GO:0048255 mRNA stabilization
GO:0050766 positive regulation of phagocytosis
GO:0050829 defense response to Gram-negative bacterium
GO:0055072 iron ion homeostasis
GO:0060586 multicellular organismal iron ion homeostasis
GO:0070574 cadmium ion transmembrane transport
GO:0070839 divalent metal ion export
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0009279 cell outer membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0070821 tertiary granule membrane
Protein Structure and Domains
PDB ID
InterPro IPR001046 NRAMP family
PFAM PF01566
PRINTS PR00447
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MJ63
UniProt Splice Variant
Entrez Gene 282470
UniGene Bt.5373
RefSeq NP_777077
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02005930 HM358028
GenPept ADI82852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca