Version 5.4
Bos taurus Protein: USP37
Summary
InnateDB Protein IDBP-696444.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP37
Protein Name Ubiquitin carboxyl-terminal hydrolase 37
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000038058
InnateDB Gene IDBG-643835 (USP37)
Protein Structure
UniProt Annotation
Function Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-630 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0016579 protein deubiquitination
GO:0035871 protein K11-linked deubiquitination
GO:0051301 cell division
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR003903 Ubiquitin interacting motif
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PF02809
PRINTS
PIRSF
SMART SM00726
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt F1N5V1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 407168
UniGene
RefSeq NP_001258921
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03077731 AAFC03103854 AAFC03103857
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca