Version 5.4
Bos taurus Protein: VEGFB
Summary
InnateDB Protein IDBP-696495.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VEGFB
Protein Name Vascular endothelial growth factor B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018089
InnateDB Gene IDBG-643900 (VEGFB)
Protein Structure
UniProt Annotation
Function Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
GO:0042803 protein homodimerization activity
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006493 protein O-linked glycosylation
GO:0007507 heart development
GO:0010629 negative regulation of gene expression
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035470 positive regulation of vascular wound healing
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060048 cardiac muscle contraction
GO:0060754 positive regulation of mast cell chemotaxis
GO:0060976 coronary vasculature development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000072 PDGF/VEGF domain
IPR029034 Cystine-knot cytokine
PFAM PF00341
PRINTS
PIRSF
SMART SM00141
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9XS49
PhosphoSite PhosphoSite-
TrEMBL G1K1P7
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB004273 AB004274 AF099134 DAAA02063529
GenPept AAG29746 BAA77685 BAA77686

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca