InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PLCB3

Summary

InnateDB Protein

IDBP-696513.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCB3

Protein Name

phospholipase C, beta 3 (phosphatidylinositol-specific)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016609

InnateDB Gene

IDBG-643906 (PLCB3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0016987	sigma factor activity

Biological Process

GO:0003073	regulation of systemic arterial blood pressure
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR013325 RNA polymerase sigma factor, region 2
IPR014815 PLC-beta, C-terminal
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF08703
PF09279

PRINTS

PR00360
PR00390

PIRSF

PIRSF000956

SMART

SM00239
SM00148
SM00149

TIGRFAMs

Post-translational Modifications

Modification

Cross-References