Version 5.4
Bos taurus Protein: PRDX5
Summary
InnateDB Protein IDBP-696531.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDX5
Protein Name Peroxiredoxin-5, mitochondrial
Synonyms Prx V;
Species Bos taurus
Ensembl Protein ENSBTAP00000011403
InnateDB Gene IDBG-643929 (PRDX5)
Protein Structure
UniProt Annotation
Function Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}. Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001016 RNA polymerase III regulatory region DNA binding
GO:0004601 peroxidase activity
GO:0005102 receptor binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046983 protein dimerization activity
GO:0051920 peroxiredoxin activity
GO:0072541 peroxynitrite reductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0016480 negative regulation of transcription from RNA polymerase III promoter
GO:0032967 positive regulation of collagen biosynthetic process
GO:0034614 cellular response to reactive oxygen species
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051354 negative regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
GO:0060785 regulation of apoptosis involved in tissue homeostasis
GO:0070995 NADPH oxidation
GO:2001057 reactive nitrogen species metabolic process
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
PFAM PF00578
PF13098
PF13192
PF13462
PF13905
PF08534
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BGI1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282885
UniGene Bt.47193
RefSeq NP_777174
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF305564 BC103073
GenPept AAG53661 AAI03074

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca