Version 5.4
Bos taurus Protein: PTK2
Summary
InnateDB Protein IDBP-696579.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTK2
Protein Name PTK2 protein tyrosine kinase 2Uncharacterized protein
Synonyms FADK;
Species Bos taurus
Ensembl Protein ENSBTAP00000056419
InnateDB Gene IDBG-643924 (PTK2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.
Predicted by orthology
Total 118 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008432 JUN kinase binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0007172 signal complex assembly
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310 phosphorylation
GO:0021955 central nervous system neuron axonogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0040023 establishment of nucleus localization
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043542 endothelial cell migration
GO:0045667 regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0050771 negative regulation of axonogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0051964 negative regulation of synapse assembly
GO:0060396 growth hormone receptor signaling pathway
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR005189 Focal adhesion kinase, targeting (FAT) domain
IPR011009 Protein kinase-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain
PFAM PF00069
PF07714
PF03623
PF00373
PRINTS PR00109
PIRSF
SMART SM00220
SM00295
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q7YRB1
UniProt Splice Variant
Entrez Gene 506270
UniGene Bt.63222
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ519780 DAAA02037523 DAAA02037524 DAAA02037525 DAAA02037526
GenPept CAD58585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca