InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FGFBP1

Summary

InnateDB Protein

IDBP-696591.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGFBP1

Protein Name

Fibroblast growth factor-binding protein 1

Synonyms

FGFBP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000042121

InnateDB Gene

IDBG-643988 (FGFBP1)

Protein Structure

UniProt Annotation

Function

Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Extracellular and plasma membrane-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017134	fibroblast growth factor binding
GO:0019838	growth factor binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR010510 FGF binding 1

PFAM

PF06473

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9MZ06

PhosphoSite

PhosphoSite-Q9MZ06

TrEMBL

Q4VS17

UniProt Splice Variant

Entrez Gene

281812

UniGene

Bt.89332

RefSeq

NP_776762

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF271896 AY642852 BC122703

GenPept

AAF75792 AAI22704 AAV34169