Version 5.4
Bos taurus Protein: EIF2C2
Summary
InnateDB Protein IDBP-696596.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2C2
Protein Name protein argonaute-2
Synonyms AGO2;
Species Bos taurus
Ensembl Protein ENSBTAP00000002068
InnateDB Gene IDBG-643987 (EIF2C2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004521 endoribonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006379 mRNA cleavage
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0009791 post-embryonic development
GO:0031047 gene silencing by RNA
GO:0031054 pre-miRNA processing
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
GO:0035279 mRNA cleavage involved in gene silencing by miRNA
GO:0045947 negative regulation of translational initiation
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0016020 membrane
GO:0016442 RISC complex
GO:0030529 ribonucleoprotein complex
GO:0035068 micro-ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR003100 PAZ domain
IPR003165 Stem cell self-renewal protein Piwi
IPR012337 Ribonuclease H-like domain
IPR014811 Domain of unknown function DUF1785
PFAM PF02170
PF02171
PF08699
PRINTS
PIRSF
SMART SM00949
SM00950
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B0JYP5
UniProt Splice Variant
Entrez Gene 404130
UniGene Bt.21912
RefSeq NP_991363
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151491 DAAA02037528 DAAA02037529 DAAA02037530
GenPept AAI51492

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca