Bos taurus Protein: ARL2 | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-696720.2 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | ARL2 | ||||||||||||||||||||||||||
Protein Name | ADP-ribosylation factor-like protein 2 | ||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Protein | ENSBTAP00000002890 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-644107 (ARL2) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. {ECO:0000269PubMed:17704193}. | ||||||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm. Mitochondrion. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}. | ||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||
Tissue Specificity | Expressed in liver and retina (at protein level). {ECO:0000269PubMed:11809823, ECO:0000269PubMed:12912990}. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR001019
Guanine nucleotide binding protein (G-protein), alpha subunit IPR001806 Small GTPase superfamily IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006687 Small GTPase superfamily, SAR1-type IPR006689 Small GTPase superfamily, ARF/SAR type IPR006762 Gtr1/RagA G protein IPR013684 Mitochondrial Rho-like IPR019009 Signal recognition particle receptor, beta subunit IPR024156 Small GTPase superfamily, ARF type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
||||||||||||||||||||||||||
PFAM |
PF00503
PF00071 PF00025 PF04670 PF08477 PF09439 |
||||||||||||||||||||||||||
PRINTS |
PR00318
PR00449 PR00328 |
||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||
SMART |
SM00275
SM00175 SM00178 SM00177 |
||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q2TA37 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 511349 | ||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||
RefSeq | NP_001033168 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | BC111133 | ||||||||||||||||||||||||||
GenPept | AAI11134 | ||||||||||||||||||||||||||