InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: THOC1

Summary

InnateDB Protein

IDBP-696734.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THOC1

Protein Name

THO complex 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025584

InnateDB Gene

IDBG-644087 (THOC1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000018	regulation of DNA recombination
GO:0006406	mRNA export from nucleus
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0031297	replication fork processing
GO:0032784	regulation of DNA-templated transcription, elongation
GO:0032786	positive regulation of DNA-templated transcription, elongation
GO:0046784	intronless viral mRNA export from host nucleus
GO:0048297	negative regulation of isotype switching to IgA isotypes
GO:2000002	negative regulation of DNA damage checkpoint

Cellular Component

GO:0000346	transcription export complex
GO:0000347	THO complex
GO:0000445	THO complex part of transcription export complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

InterPro

IPR000488 Death domain
IPR002919 Trypsin Inhibitor-like, cysteine rich domain
IPR011029 Death-like domain
IPR021861 THO complex, subunit THOC1
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00531
PF01826
PF11957

PRINTS

PIRSF

SMART

SM00005

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite