InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2O

Summary

InnateDB Protein

IDBP-69679.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2O

Protein Name

ubiquitin-conjugating enzyme E2O

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323687

InnateDB Gene

IDBG-69677 (UBE2O)

Protein Structure

UniProt Annotation

Function

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin- associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269PubMed:23381138, ECO:0000269PubMed:23452853, ECO:0000269PubMed:23455153, ECO:0000269PubMed:24703950}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:24703950}. Nucleus {ECO:0000269PubMed:24703950}. Note=Mainly localizes to the cytoplasm.

Disease Associations

Tissue Specificity

Predominantly expressed in skeletal muscle and heart. {ECO:0000269PubMed:11311559}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006513	protein monoubiquitination
GO:0030513	positive regulation of BMP signaling pathway
GO:0042147	retrograde transport, endosome to Golgi
GO:0070534	protein K63-linked ubiquitination