Version 5.4
Bos taurus Protein: DRAP1
Summary
InnateDB Protein IDBP-696948.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRAP1
Protein Name Dr1-associated corepressor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008142
InnateDB Gene IDBG-644314 (DRAP1)
Protein Structure
UniProt Annotation
Function The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). {ECO:0000250UniProtKB:Q14919}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:Q14919}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2YDP3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540345
UniGene
RefSeq NP_001069682
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110127
GenPept AAI10128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca