Version 5.4
Bos taurus Protein: TBXA2R
Summary
InnateDB Protein IDBP-697031.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBXA2R
Protein Name Thromboxane A2 receptor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019892
InnateDB Gene IDBG-644398 (TBXA2R)
Protein Structure
UniProt Annotation
Function Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004960 thromboxane receptor activity
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0019229 regulation of vasoconstriction
GO:0019932 second-messenger-mediated signaling
GO:0032496 response to lipopolysaccharide
GO:0045987 positive regulation of smooth muscle contraction
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001105 Thromboxane receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
PFAM PF00001
PF10323
PRINTS PR00237
PR00429
PR01788
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95125
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 538783
UniGene Bt.4053
RefSeq NP_001161391
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U53484 U53485
GenPept AAC34308 AAC34309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca