InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CX3CR1

Summary

InnateDB Protein

IDBP-697037.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CX3CR1

Protein Name

CX3C chemokine receptor 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003797

InnateDB Gene

IDBG-644403 (CX3CR1)

Protein Structure

UniProt Annotation

Function

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004896	cytokine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016495	C-X3-C chemokine receptor activity

Biological Process

GO:0002282	microglial cell activation involved in immune response
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0021795	cerebral cortex cell migration
GO:0048246	macrophage chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR005384 Duffy antigen/chemokine receptor
IPR005387 CX3C chemokine receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR01559
PR01562

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QNL7