InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DOHH

Summary

InnateDB Protein

IDBP-697057.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOHH

Protein Name

Deoxyhypusine hydroxylase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006935

InnateDB Gene

IDBG-644423 (DOHH)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor. {ECO:0000255HAMAP-Rule:MF_03101, ECO:0000269PubMed:17391984}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0019135	deoxyhypusine monooxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR004155 PBS lyase HEAT-like repeat
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2

PFAM

PF03130

PRINTS

PIRSF

SMART

SM00567

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VC53

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

526521

UniGene

Bt.10480

RefSeq

NP_001069354

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120351 DQ990881 DQ990882 DQ990883

GenPept

AAI20352 ABL86660 ABL86661 ABL86662