InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDE6D

Summary

InnateDB Protein

IDBP-697080.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE6D

Protein Name

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025947

InnateDB Gene

IDBG-644439 (PDE6D)

Protein Structure

UniProt Annotation

Function

Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0007601	visual perception
GO:0008152	metabolic process
GO:0033124	regulation of GTP catabolic process
GO:0043086	negative regulation of catalytic activity
GO:0050896	response to stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR008015 GMP phosphodiesterase, delta subunit
IPR014756 Immunoglobulin E-set
IPR017287 Retinal rod rhodopsin-sensitive cGMP 3\', 5\'-cyclic phosphodiesterase, delta subunit

PFAM

PF05351

PRINTS

PIRSF

PIRSF037825

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q95142