InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ASPH

Summary

InnateDB Protein

IDBP-697177.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASPH

Protein Name

Aspartyl/asparaginyl beta-hydroxylase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021267

InnateDB Gene

IDBG-644533 (ASPH)

Protein Structure

UniProt Annotation

Function

Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269PubMed:1856229}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004597	peptide-aspartate beta-dioxygenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0007389	pattern specification process
GO:0008285	negative regulation of cell proliferation
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0018193	peptidyl-amino acid modification
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031647	regulation of protein stability
GO:0032237	activation of store-operated calcium channel activity
GO:0033198	response to ATP
GO:0035108	limb morphogenesis
GO:0042264	peptidyl-aspartic acid hydroxylation
GO:0045862	positive regulation of proteolysis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0070588	calcium ion transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0090316	positive regulation of intracellular protein transport
GO:0097202	activation of cysteine-type endopeptidase activity
GO:1901879	regulation of protein depolymerization

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0032541	cortical endoplasmic reticulum

Protein Structure and Domains

PDB ID

InterPro

IPR007803 Arginine/Asparagine/Proline hydroxylase
IPR007943 Aspartyl beta-hydroxylase/Triadin domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF05118
PF05279
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q28056