Version 5.4
Bos taurus Protein: SLC14A1
Summary
InnateDB Protein IDBP-697184.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC14A1
Protein Name Urea transporter 1
Synonyms RACH1; UT-1; UT-B;
Species Bos taurus
Ensembl Protein ENSBTAP00000044109
InnateDB Gene IDBG-644539 (SLC14A1)
Protein Structure
UniProt Annotation
Function Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. {ECO:0000269PubMed:15845882, ECO:0000269PubMed:22733730}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Restricted to the basolateral membrane in various portions of the urothelium.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are expressed in kidney. Also expressed in the rumen (at protein level). Isoform 2 seems predominant in both tissues. {ECO:0000269PubMed:15845882}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005372 water transmembrane transporter activity
GO:0015204 urea transmembrane transporter activity
GO:0015265 urea channel activity
Biological Process
GO:0006810 transport
GO:0006833 water transport
GO:0015840 urea transport
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR004937 Urea transporter
PFAM PF03253
PRINTS
PIRSF PIRSF016502
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5QF96
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 493988
UniGene Bt.66422
RefSeq XP_005224169
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY624602 AY838799 BC105333
GenPept AAI05334 AAU94647 AAW02793 AAW51203

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca