InnateDB Protein
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IDBP-697188.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC14A1
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Protein Name
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Urea transporter 1
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Synonyms
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RACH1; UT-1; UT-B;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000026475
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InnateDB Gene
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IDBG-644539 (SLC14A1)
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Protein Structure
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Function |
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. {ECO:0000269PubMed:15845882, ECO:0000269PubMed:22733730}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Restricted to the basolateral membrane in various portions of the urothelium.
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Disease Associations |
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Tissue Specificity |
Isoform 1 and isoform 2 are expressed in kidney. Also expressed in the rumen (at protein level). Isoform 2 seems predominant in both tissues. {ECO:0000269PubMed:15845882}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0015204
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urea transmembrane transporter activity
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GO:0015265
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urea channel activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004937
Urea transporter
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PFAM |
PF03253
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PRINTS |
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PIRSF |
PIRSF016502
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5QF96
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
493988
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UniGene |
Bt.66422
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RefSeq |
NP_001008666
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AY624602
AY838799
BC105333
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GenPept |
AAI05334
AAU94647
AAW02793
AAW51203
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