Version 5.4
Bos taurus Protein: RDH10
Summary
InnateDB Protein IDBP-697434.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDH10
Protein Name Retinol dehydrogenase 10
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026830
InnateDB Gene IDBG-644770 (RDH10)
Protein Structure
UniProt Annotation
Function Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). {ECO:0000250}.
Subcellular Localization Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in retinal pigment epithelium (at protein level). Detected in retina, retinal pigment epithelium, and at lower levels in cornea, liver, kidney, pancreas, lung, brain and skeletal muscle. {ECO:0000269PubMed:12407145, ECO:0000269PubMed:15505029}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0052650 NADP-retinol dehydrogenase activity
Biological Process
GO:0001656 metanephros development
GO:0001701 in utero embryonic development
GO:0002138 retinoic acid biosynthetic process
GO:0007601 visual perception
GO:0008152 metabolic process
GO:0008406 gonad development
GO:0009887 organ morphogenesis
GO:0014032 neural crest cell development
GO:0031076 embryonic camera-type eye development
GO:0035115 embryonic forelimb morphogenesis
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0043583 ear development
GO:0043584 nose development
GO:0048568 embryonic organ development
GO:0048703 embryonic viscerocranium morphogenesis
GO:0055114 oxidation-reduction process
GO:0060431 primary lung bud formation
GO:0060449 bud elongation involved in lung branching
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8HZT6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282852
UniGene Bt.12765
RefSeq NP_777159
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF456766 BC134557
GenPept AAI34558 AAN64748

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca