Version 5.4
Bos taurus Protein: TCEB1
Summary
InnateDB Protein IDBP-697447.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCEB1
Protein Name Transcription elongation factor B polypeptide 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002843
InnateDB Gene IDBG-644782 (TCEB1)
Protein Structure
UniProt Annotation
Function SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). {ECO:0000250}.The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.
Predicted by orthology
Total 114 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0070449 elongin complex
Protein Structure and Domains
PDB ID
InterPro IPR001232 SKP1 component
IPR011333 BTB/POZ fold
IPR016073 SKP1 component, POZ domain
PFAM PF03931
PRINTS
PIRSF
SMART SM00512
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KII4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540859
UniGene
RefSeq NP_001039958
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112626
GenPept AAI12627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca