Version 5.4
Bos taurus Protein: IL7
Summary
InnateDB Protein IDBP-697491.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL7
Protein Name Interleukin-7
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021659
InnateDB Gene IDBG-644827 (IL7)
Protein Structure
UniProt Annotation
Function Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005139 interleukin-7 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0002360 T cell lineage commitment
GO:0006955 immune response
GO:0010468 regulation of gene expression
GO:0030890 positive regulation of B cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0045453 bone resorption
GO:0045582 positive regulation of T cell differentiation
GO:0046622 positive regulation of organ growth
GO:0048873 homeostasis of number of cells within a tissue
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000226 Interleukin-7/interleukin-9 family
IPR001181 Interleukin-7
PFAM PF01415
PRINTS PR00435
PIRSF PIRSF001942
SMART SM00127
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26895
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280827
UniGene Bt.12751
RefSeq NP_776349
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142466 EU276072 X64540
GenPept AAI42467 ABX72070 CAA45838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca