InnateDB Protein
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IDBP-697505.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CRBN
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Protein Name
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Protein cereblon
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000026031
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InnateDB Gene
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IDBG-644836 (CRBN)
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Protein Structure
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Function |
Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003111
Peptidase S16, lon N-terminal
IPR015947
PUA-like domain
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PFAM |
PF02190
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PRINTS |
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PIRSF |
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SMART |
SM00464
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TIGRFAMs |
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Modification |
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SwissProt |
Q0P564
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
511585
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UniGene |
Bt.95525
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RefSeq |
NP_001068995
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC120452
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GenPept |
AAI20453
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