Version 5.4
Bos taurus Protein: EXT1
Summary
InnateDB Protein IDBP-697550.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXT1
Protein Name Exostosin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008154
InnateDB Gene IDBG-644880 (EXT1)
Protein Structure
UniProt Annotation
Function Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008375 acetylglucosaminyltransferase activity
GO:0015020 glucuronosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
Biological Process
GO:0001503 ossification
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006486 protein glycosylation
GO:0007369 gastrulation
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007492 endoderm development
GO:0007498 mesoderm development
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0021772 olfactory bulb development
GO:0033692 cellular polysaccharide biosynthetic process
GO:0072498 embryonic skeletal joint development
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR004263 Exostosin-like
IPR015338 EXTL2, alpha-1,4-N-acetylhexosaminyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF03016
PF09258
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5D7I4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 538602
UniGene Bt.19542
RefSeq NP_001091564
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140568
GenPept AAI40569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca