InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MED30

Summary

InnateDB Protein

IDBP-697552.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED30

Protein Name

Mediator of RNA polymerase II transcription subunit 30

Synonyms

THRAP6; Trap25;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009150

InnateDB Gene

IDBG-644883 (MED30)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0019827	stem cell maintenance
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

InterPro

IPR021019 Mediator complex, subunit Med30, metazoa

PFAM

PF11315

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2YDF2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613879

UniGene

Bt.22622

RefSeq

NP_001073086

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC110250

GenPept

AAI10251