Version 5.4
Bos taurus Protein: CEP120
Summary
InnateDB Protein IDBP-697617.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP120
Protein Name Centrosomal protein of 120 kDa
Synonyms CCDC100;
Species Bos taurus
Ensembl Protein ENSBTAP00000041320
InnateDB Gene IDBG-644943 (CEP120)
Protein Structure
UniProt Annotation
Function Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0008283 cell proliferation
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0022027 interkinetic nuclear migration
GO:0030953 astral microtubule organization
GO:0032880 regulation of protein localization
GO:0032886 regulation of microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR022136 Domain of unknown function DUF3668
PFAM PF00168
PF12416
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0JN62
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534400
UniGene Bt.59429
RefSeq XP_005209165
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03099167 AAFC03099169 AAFC03125142 AAFC03125893 AAFC03126660 AAFC03131164 BC126531
GenPept AAI26532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca