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InnateDB Protein
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IDBP-697677.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNFAIP8
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Protein Name
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Tumor necrosis factor alpha-induced protein 8
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000019342
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InnateDB Gene
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IDBG-645003 (TNFAIP8)
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Protein Structure
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| Function |
Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
5 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0043027
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cysteine-type endopeptidase inhibitor activity involved in apoptotic process
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| Biological Process |
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GO:0006915
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apoptotic process
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GO:0032611
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interleukin-1 beta production
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GO:0043154
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0050830
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defense response to Gram-positive bacterium
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR008477
Protein of unknown function DUF758
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| PFAM |
PF05527
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
A4IF78
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
529336
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| UniGene |
Bt.36160
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| RefSeq |
NP_001077180
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC134442
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| GenPept |
AAI34443
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Version 5.4