InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FGFR4

Summary

InnateDB Protein

IDBP-697857.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGFR4

Protein Name

fibroblast growth factor receptor 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013942

InnateDB Gene

IDBG-645171 (FGFR4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008201	heparin binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0001759	organ induction
GO:0006468	protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010715	regulation of extracellular matrix disassembly
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019216	regulation of lipid metabolic process
GO:0030324	lung development
GO:0042593	glucose homeostasis
GO:0045862	positive regulation of proteolysis
GO:0046777	protein autophosphorylation
GO:0048554	positive regulation of metalloenzyme activity
GO:0055062	phosphate ion homeostasis
GO:0061144	alveolar secondary septum development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070857	regulation of bile acid biosynthetic process
GO:2000188	regulation of cholesterol homeostasis
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

PIRSF000628

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References