InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PTDSS1

Summary

InnateDB Protein

IDBP-697894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTDSS1

Protein Name

phosphatidylserine synthase 1

Synonyms

PSS-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018461

InnateDB Gene

IDBG-645205 (PTDSS1)

Protein Structure

UniProt Annotation

Function

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016740	transferase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006659	phosphatidylserine biosynthetic process
GO:0008654	phospholipid biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004277 Phosphatidyl serine synthase

PFAM

PF03034

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KHY9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509819

UniGene

Bt.17659

RefSeq

NP_001039505

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112833 DAAA02039445

GenPept

AAI12834