Version 5.4
Bos taurus Protein: STMN1
Summary
InnateDB Protein IDBP-697945.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STMN1
Protein Name Stathmin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018284
InnateDB Gene IDBG-645253 (STMN1)
Protein Structure
UniProt Annotation
Function Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015631 tubulin binding
Biological Process
GO:0007019 microtubule depolymerization
GO:0007052 mitotic spindle organization
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0009615 response to virus
GO:0030154 cell differentiation
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0031115 negative regulation of microtubule polymerization
GO:0051272 positive regulation of cellular component movement
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000956 Stathmin family
PFAM PF00836
PRINTS PR00345
PIRSF PIRSF002285
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0C7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 616317
UniGene Bt.3137
RefSeq NP_001029962
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102453
GenPept AAI02454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca